Monsanto has set a goal to double the yield of major crops to meet the growing global demands.  These yields are most often limited by abiotic stresses that are encountered during the growing season.  There is also an expectations that future products must require less inputs, such as nutrients and water, to produce a given unit of yield increase.  Transgenes that improve the nutrient and water use efficiencies of plants have been identified and examples of the physiological improvements imparted will be shown.  An outlook on the work required to convert those discoveries into commercial products will be discussed.