Crabgrass is a common turfgrass weed in the upper Midwest. Preemergence herbicides are used to control crabgrass and are often applied using sequential applications for season- long control. It is typically recommended based on early 1990’s research, to use the same active ingredient for both the initial and sequential applications. However, this recommendation should be revisited with new preemergence chemistries available and the potential for increased flexibility to the end-user. The objective of this study was to determine if using a different herbicide for the initial and sequential application would affect season-long crabgrass control. The study was conducted in Indiana in 2009, 2010, and 2011 and in two locations in Nebraska in 2011. Initial applications of one half the high label rate of dithiopyr, pendimethalin, or prodiamine were applied in mid April and then followed with all combinations of one half the high label rate of the same three herbicides.  Percent crabgrass cover was visually rated in mid June and August. From the first 2 years data, no difference in August crabgrass cover was seen when either the same or different active ingredients were used for the initial and sequential applications.