Soybean [Glycine max (L.) Merr.] cultivar S05-11482 was developed at the University of Missouri- Delta Research Center, Portageville, MO and released by the University of Missouri Agricultural Experiment Station in 2010. It is an F₄ plant selection composited in F₅ generation from a cross of S99-2281 x S00-9985-03. S05-11482 is a late group IV-early maturity group V (relative maturity 4.9-5.0) conventional soybean line with excellent yield potential across soil types. It is resistant to frogeye leaf spot (Cercospora sojina K. Hara) and southern root knot nematode [Meloidogyne incognita (Kofoid & White) Chitwood]. It is moderately resistant to soybean cyst nematode (SCN) (Heterodera glycines Ichinohe) races 1, 2, 3, 5 and 14. Also, it is moderately resistant to stem canker [Diaporthe phaseolorum (Cooke and Ellis) Sacc. var. meridionales F. A. Fernandez] and is moderately resistant to sudden death syndrome (SDS) [Fusarium solani (Mort.) Sacc. f. sp. glycines Roy]. Yield tests over four years and a total of 20 locations in southeast Missouri show that S05-11482 yields better than AG4903, a widely grown late group IV high yielding Roundup Ready cultivar of similar maturity. In the USDA Preliminary and Uniform Tests of Southern States from 2008 to 2010 in 47 locations, the yield of S05-11482 was better than widely grown high yielding Roundup Ready group V  cultivars ‘Asgrow AG5605’ ‘Asgrow AG5606’  and the conventional cultivar ‘5601T’. S05-11482 will provide soybean growers a very productive, conventional soybean cultivar with broad resistance to important disease and nematode species.