Potato production on sandy soils is complicated by the conflicting goals of maximizing yield and minimizing nitrogen (N) loss through leaching. Controlling the rate of N release to match the potato plant demands maximizes plant productivity and minimize potential N loss. Two experiments were conducted on sandy soils of Central Wisconsin to evaluate the effect of several slow- or controlled-release fertilizer products (Environmentally Smart Nitrogen ™ (ESN), SuperU ™, Agrotain ™, and Polyon™) on potato yields and nitrate leaching compared to the conventional fertilizer treatments. Pan lysimeters and porous cup samplers were used to quantify drainage and nitrate concentrations in the leachate.  ESN™ consistently produced yields comparable to, or exceeding, conventional fertilizer treatment yields. Moreover, nitrate concentrations in the leachate from the ESN ™ and SuperU™ plots  were also lower than the conventional fertilizer treatment.  Environmental conditions, such as amount and timing of precipitation, had a large effect on the effectiveness of enzyme inhibitor-driven products.