Emerging micropollutants, such as pharmaceuticals and endocrine disrupting chemicals (EDCs), present a challenge to conventional water and wastewater treatment technologies. We in our recent studies demonstrated that enzyme catalyzed oxidative coupling processes (ECOCP) may provide an alternative approach to the effective removal of micropollutants from water. ECOCP involves catalysis by enzymes having specific binding capacities for both the micropollutants and the oxidants (H₂O ₂, O₂), so that the processes are more amenable to deal with low-concentration contaminants, requiring less oxidant and energy input. Our data help to understand the mechanisms involved in micropollutants transformation, removal and toxicity reduction, as well as the influence of relevant environmental conditions such as pH and dissolved organic matter. Potential means to incorporate ECOCP in conventional water/wastewater treatment procedure or for water reuse will be discussed.