About 5.22 million of the estimated 12.6 million tons of nitrogen (N) consumed in the United States in 2008 was used for corn production (USDA-ERS, 2010).  Excessive use of N fertilizers during corn production coupled with low nitrogen use efficiency of corn can result in soil nitrous oxide (N₂O) emissions.  World wide, agricultural N₂O emissions are projected to increase 35-60% by 2030 due to increased N fertilizer use and animal manure production (FAO, 2003). Although, relatively great amount of research has been conducted to determine the effect of various tillage and N management systems on N₂O emissions, results vary widely, and opinion remain divided as to the effects of these management systems.   In particular, limited data exist to assess N₂O emissions following spring sidedress-applied N treated with reformulated nitrapyrin - Instinct™ - especially designed for application with liquid N fertilizers.  On-farm experiments were initiated across Indiana to determine the effect of N fertilizer and “Instinct™” management on seasonal N₂O emission patterns under different tillage practices, determine the effects of a “Instinct™” on N₂O emissions following liquid N fertilizer application and, evaluate the relationship between N application rates and N₂O emission intensity from sidedressed N in cornfields.  Our results indicated that both no-till and the use of the nitrification inhibitor (Instinct™) caused dramatic reductions in N₂O emissions; the magnitude of reduction depended on location.  Nitrous oxide emission was up to 46% less under NT compared to tilled systems.  Depending on soil drainage conditions, addition of Instinct™ to side-dressed UAN fertilizer lowered N₂O emissions by up to 53% in the four counties with on-farm trials. We found that exceeding recommended N fertilizer rates by 30 to 60 pounds N per acre resulted in about 72-100% increase in N₂O emissions.  Soil N₂O emissions were mainly driven by soil temperature and moisture conditions, and addition of the nitrification inhibitor reduced soil mineral nitrogen concentrations for a longer period during the growing season.