Pollution and heavy metals contamination have received much attention with regard to accumulation in soils, uptake by plants and impurities of waters. In Great Cairo City, different factories get rid of large amounts of wastewater, which contain heavy metals without adequate treatment as sewage. With expected water deficiency, sewage water is planned to be used for irrigation in some areas. In addition, metals can be introduced into the soil from various human activities involving processing, manufacturing of paints and pigments, atmospheric emission from motor vehicles, incineration of municipal solid wastes and combustion of coal … etc. One of the most important sources of soil contamination with heavy metals is mineral fertilizers. This research was carried out to investigate and assess the risk of heavy metals like arsenic, cadmium, chromium, mercury and lead. Two regions in Egypt were selected for this study, the first region in Sinai Governorate, which is considered to be uncontaminated area. The second in Abou-Rawash fields which is irrigated with the wastewater of Great Cairo City. Heavy metals were determined by two spectroscopic techniques: atomic emission and atomic absorption spectroscopy. The obtained results indicate that comparing the concentration of heavy metals in Sinai soil samples are free from contaminated pollutant with heavy elements. Regarding Abou-Rawash soils, although the concentration of total content is multiple (2 times for Cr, 10 times for Hg, 6 times for CD) of permissible toxic level ,yet effective available content for plant is less than the toxic level (tables 1&2).