Crop management strategies that improve Nitrogen Use Efficiency (NUE) obviously increase farm profits while reducing the deleterious effects on the environment associated with fertilizer N loss from the soil system. Effective N management should include several critical factors that are very interrelated. A study was conducted at the Panhandle Research and Extension Center, Goodwell, OK to evaluate the effects of multiple nitrogen management practices including N rate, source, time of application, methods of fertilizer and residue incorporation over a long period of time on grain yield, N uptake and NUE in irrigated corn in Oklahoma. Fourteen treatments that contained the aforementioned N management practices were evaluated in a Randomized Complete Block Design with three replicates. Results of the individual year and averages of all years showed that grain yield and N uptake were improved compared to checks. Both N recovery and efficiency of use were high for the 118 kg N ha-1 rate. Generally the use of either urea or anhydrous ammonia did not affect the response variables.