Grain yield must be increased to meet increasing food demand. The challenge for higher yields of production systems requires greater productive efficiency of nitrogen (N), water and land, with the least possible impact on the environment. The development and implementation of tested practices of crop management are essential to ensure the necessary increases of productivity for the next decades. The objective of this work was to study the effect of a technology package sustainably intensified that combines the best crop management practices on yield, water productivity (WP) and nitrogen use efficiency (NUE) in maize. Three years of maize were evaluated in a long-term experiment started in 2009 at Balcarce, Argentina (37°45’S, 58°18’W) with a maize-wheat/soybean sequence under no-till system. Two crop management systems were compared: i) average farmer management (AP), and ii) sustainable intensified management (IS), which includes the use of high potential cultivars with herbicide, diseases and pests resistance; optimized plant density and row spacing and the best management practices of fertilization. Yield, WP, NUE and their respective components were determined. Management intensification resulted in higher yield and more efficient resources and inputs use. N uptake was higher for IS than for AP crop management. Physiological N efficiency was not reduced with IS management despite the N availability and uptake increased. Intensified management did not affect water consumption, but increased water use efficiency in two of the three evaluated years. This experiment combines the effects of various management practices that had been shown to have positive individual effects on maize productivity. This type of experiments integrates the many interactions among management practices that arise at a production system. These results have relevant economic and environmental implications.