Genetic advances in wheat (Triticum aestivum) and increased yield potential there may be a need for secondary and micronutrients. The objective of this study was to evaluate the wheat response to sulfur and micronutrient fertilization with an emphasis on high yield environments, and evaluate soil testing and tissue analysis as a diagnostic tool to explain responses to micronutrient application. Seven locations were established in 2012-2013 in locations with high yield potential. All locations were established in under dryland conditions under conventional tillage system. Fertilizer treatments consisted of topdress sulfur, iron, manganese, zinc, boron, copper. All of the micronutrients were sulfate based products and the sulfur treatments were applied as gypsum. Fertilizer treatments were applied in the early spring prior to feekes 4.  Soil samples were collected and analyzed from pre-fertilizer application and post-harvest. Tissue samples were collected at feekes 8 and analyzed for the nutrients applied with the fertilizer treatments. Results across locations indicated that the application of micronutrients did not have a significant impact on yield.