Biotechnology has played an important role for improving crop yields. Currently, the world crop and food production are facing many challenges such as increasing population, climate change, reducing water resources, and environmental degradation, etc. Can biotechnology continue to play important roles in the world food security with these challenges?  The objective of this symposium is to provide a forum for scientists from US, China, and other parts of the world to exchange experiences, discuss ideas, and debate solutions regarding the issues of how the biotechnology can impact crop production and food security in the changing world and climate.