There is considerable interest on the impact of veterinary antibiotic use on human and livestock health. While there is a general idea of how antibiotic resistance (AR) is transferred from animals to humans via food and water, manure and manure management play a critical role in this issue. Manure is how both the antibiotics from animal feed and the AR intestinal bacteria enter the environment. The goal of this symposium is to explore the prevalence, fate, and transport of antibiotics, AR bacteria, and AR genes, as well as solutions to the AR issue in both agricultural and non-agricultural settings.